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A recent Cam-CAN study led by Rik Henson shows how age-related differences in three types of memory depend on age-related differences in both the gray-matter integrity of key brain regions and the integrity of white-matter connections between them.Download Publication From middle-age, the brains of obese individuals display differences in white matter similar to those in lean individuals ten years their senior, according to new research led by the University of Cambridge.Download Publication Using non-invasive functional Magnetic Resonance Imaging (f MRI) and cutting-edge algorithms, Cam-CAN researchers have developed a new technique to probe the communication patterns between different parts of the human brain.We hope that this technique will give us a clearer picture of how brain connectivity changes during the ageing process, and whether this has a significant effect on cognition.These findings provide insights into why some skills are more vulnerable to age-related decline while others are preserved.The ability to solve abstract reasoning problems, sometimes known as ‘fluid intelligence’, plays a central role in many day-to-day activities across the lifespan.

Download Publication Many of us experience memory problems as we grow older, but did you know that different types of memory change at different rates?

Given the complexity and speed of this process, it is remarkably well preserved with age.

Karen Campbell and colleagues challenge the conventional approach to neurocognitive aging by showing that the neural underpinnings of a given cognitive function depend on how you test it.

At the same time, age-related delay to auditory stimulation is partly explained by damage to grey matter in the auditory cortex.

This study is the first to find such a relationship providing important clues regarding the biological origins of cognitive decline.

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The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) is a large-scale collaborative research project, launched in October 2010, with substantial funding from the Biotechnology and Biological Sciences Research Council (BBSRC).

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